What's the right aspirin dose for CVD patients?

Results of a new pragmatic trial called ADAPTABLE will give clinicians and their patients with heart disease more to discuss when it comes the right dose aspirin needed prevent another attack or stroke. Researchers evaluated taken at 81 mg per day compared 325 among established atherosclerotic cardiovascular (ASCVD). The study findings, which were published on May 27, 2021, in New England Journal Medicine, failed show that was superior ASCVD. “This clinical question has vexed many my fellow pharmacists from days we learned about cardioprotection therapy school,” said Kevin Haynes, PharmD, research organization HealthCore, helped recruit for study. Aspirin is recommended primary prevention CVD high-risk patients, but there been long-standing debate over best dosage this commonly used medication, especially since purchased counter. advances evidence as assist aisles our stores navigating discussion doctors dose,” Haynes. “Studying over-the-counter drugs always challenge recruitment patient engagement like sets stage what possible large trials,” virtual involving 15,076 participants Patients randomly assigned followed approximately 2 years. found no differences rates death, hospitalization stroke, bleeding between who took those day. effectiveness outcome, assessed time-to-event analysis, composite death any cause; myocardial infarction; safety outcome major bleeding. Overall, these endpoints, also adherence. Over course trial, team likely switch doses stop taking than people (42% vs. 7%, respectively). This switching discontinuation may have affected results, W. Schuyler Jones, MD, lead author “The fact didn’t during had better outcomes interesting,” an interventional cardiologist Duke University Health System. “Possibly, medical reasons dose—such atrial fibrillation, cancer diagnosis, percutaneous coronary intervention,” he continued. thinks take-away message appropriate most disease. “But tolerated time should speak staying said. People following dosing guidelines clinicians:▪If you are now, probably two doses.▪If resuming aspirin, starting lower (81 mg) due tolerability. There conclusive higher better.▪If now doing okay, consider dose.Source: theaspirinstudy.org/ dose. Source: